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学科主题: 高分子化学
题名: Honeycomb-Structured Films by Multifunctional Amphiphilic Biodegradable Copolymers: Surface Morphology Control and Biomedical Application as Scaffolds for Cell Growth
其他题名: 功能化两亲性生物降解性嵌端共聚物制备蜂窝状薄膜及其作为细胞培养支架的应用
作者: Zhu YD(朱英丹) ; Sheng RL(盛瑞隆) ; Luo T(罗挺) ; Li H(李慧) ; Sun JJ(孙景景) ; Chen SD(陈圣典) ; Sun WY(孙文艳) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: ACS Appl. Mater. Interfaces
发表日期: 2011
卷: 3, 期:7, 页:2487-2495
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Recently, fabrication of functional porous polymer films with patterned surface structures at the scale from nanometer to micrometer has been attracting increasing interests in material science and nanobiotechnology. In this work, we present new preparation of two series of multifunctional amphiphilic copolymers and preparation of their microporous thin films on solid substrates. First, diblock dendritic poly(l-lysine)-b-poly(l-lactide)s and triblock dendritic poly(l-lysine)-b-poly(l-lactide)-b-dendritic poly(l-lysine)s (C1-C6) were synthesized through 4-dimethylaminopyridine (DMAP)-catalyzed living ring-opening polymerization of (l-)-lactide with (l-)-lysine dendron initiators, and their structures were characterized by nuclear magnetic resonance spectrometer (NMR), gel permeation chromatography (GPC) and matrix-assisted laser desorption/ionization Fourier-transformed mass spectra (MALDI-FTMS). Employing the breath-figure (BF) fabrication strategy, thin films of the synthesized amphiphiles (C1-C6) were drop-cast, and their surface topologies were examined by scanning electron microscopy (SEM) and atomic force microscopy (AFM), and the effects of new amphiphile structure and drop-casting parameters of amphiphile concentration, humidity and temperature on self-assembly of ordered porous surface were studied. Furthermore, the influence of surface energy Of drop-casting substrates was additionally investigated. With a human cervical epithelial carcinoma cell line (HeLa), cytotoxicity,of the prepared honeycomb-structured films by new amphiphile C6 was evaluated by thiazoyl-blue-tetrazolium-bromide (MTT) assay, and HeLa cell growth behavior with microporous amphiphile films as the scaffolds was also examined. It was found that tunable micropore diameter sizes and well ordered surface topologies of BF films could be achieved for the new prepared amphiphiles, and utilization of the honeycomb-like microporous films as scaffolds indicated favorable enhancement in cell proliferation. Therefore, the honeycomb-structured films by these biocompatible multifunctional amphiphiles may provide new materials as 3D-scaffold materials for potential application in tissue engineering and regeneration.
语种: 英语
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WOS记录号: WOS:000293196800047
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22966
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
Zhu YD,Sheng RL,Luo T,et al. Honeycomb-Structured Films by Multifunctional Amphiphilic Biodegradable Copolymers: Surface Morphology Control and Biomedical Application as Scaffolds for Cell Growth[J]. ACS Appl. Mater. Interfaces,2011,3(7):2487-2495.
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