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学科主题: 高分子化学
题名: Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers
其他题名: 两亲性树枝状赖氨酸-聚乳酸-树枝状赖氨酸的溶液自组装与基因转染行为
作者: Zhu YD(朱英丹) ; Sheng RL(盛瑞隆) ; Luo T(罗挺) ; Li H(李慧) ; Sun WY(孙文艳) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: Macromol. Biosci.
发表日期: 2011
卷: 11, 期:2, 页:174-186
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: A new series of triblock [dendritic poly(L-lysine)]-block-PLLA-block-[dendritic poly(L-lysine)]s(DL2-PLLA-DL2) with PLLA block lengths of 11.5-26.5 and double 2-generation PLL dendrons DL2 as model cationic amphiphiles were synthesized and characterized. Their CAC, self-aggregation and plasmid DNA binding affinities in pure water and PBS were studied. The PLLA block length dependence of particle size, morphology and xi potential for organized pDNA/amphiphile polyplex aggregates were examined. Finally, toxicities of these DL2-PLLA-DL2 amphiphiles and their polyplexes were assayed by MTT with HeLa, SMMC-7721 and COS-7 cells, and COS-7 cell luciferase and eGFP gene transfection efficacies with these amphiphiles as the delivery carriers were investigated.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000287162800002
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22958
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
Zhu YD,Sheng RL,Luo T,et al. Amphiphilic Cationic [Dendritic poly(L-lysine)]-block-poly(L-lactide)-block-[dendritic poly(L-lysine)]s in Aqueous Solution: Self-Aggregation and Interaction with DNA as Gene Delivery Carriers[J]. Macromol. Biosci.,2011,11(2):174-186.
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