中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 高分子材料研究室  > 期刊论文
学科主题: 高分子化学
题名: 新型结合阿霉素的聚乙二醇嵌段共聚树枝状聚赖氨酸的合成及其药物缓释行为的研究
其他题名: Preparation of New Poly(ethylene glycol)-block-Dendritic Poly(l-lysine)s Conjugated with Doxorubicin and Its Controlled Drug Release
作者: 夏可嘉 ; 盛瑞隆 ; 朱英丹 ; 李慧 ; 罗挺 ; 徐宇虹 ; 曹阿民
通讯作者: 徐宇虹 ; 曹阿民
刊名: 化学学报
发表日期: 2010-01-01
卷: 68, 期:11, 页:1130-1136
收录类别: SCI
部门归属: 上海交通大学; 中国科学院上海有机化学研究所
英文摘要: Water-soluble methoxy poly(ethylene glycol)-block-dendritic poly(l-lysine) MPEG-block-DPL4 with 4 generation PLL was synthesized with well-defined structure. Further, their PLL dendron surface amino groups were modified by hydrazine, and were succesively conjugated with antitumor doxorubicin via a pH-sensitive N=C hydrazone linkage. UV-Vis spectra were hereby employed for the prepared MPEG-block-DPL4-CONHN=DOX to quantify the efficiencies of transferring dendron surface function groups and newly attaching doxorubicin molecules. Moreover, the new doxorubicin-conjugated polymeric MPEG-block-DPL4-CONHN=DOX was utilized to explore drug release behavior under various pH environments, and indicating that the polymeric drug was quite stable under the physiological condition (pH=7.4) while its DOX drug release was accelerated under acidic condition (pH=4.5, 5.5). Concerning the cytotoxcity of new synthesized polymeric drug, in-vitro cell toxcity assayed by MTT with human hepatocarcinoma cell-line SMMC-7721 and human lung carcinoma cell-line SPCA-1 clearly demonstrated that the new MPEG-block-DPL4-CONHN=DOX showed much lowered cell toxicities than the control of free doxorubicin. Therefore, this low toxcity doxorubicin-conjugated polymeric molecule may be further developed as potential pH-responsive antitumor drug carriar with controlled release of doxorubicin.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22954
Appears in Collections:高分子材料研究室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2010231.pdf(912KB)----开放获取--View Download

Recommended Citation:
夏可嘉,盛瑞隆,朱英丹,等. 新型结合阿霉素的聚乙二醇嵌段共聚树枝状聚赖氨酸的合成及其药物缓释行为的研究[J]. 化学学报,2010,68(11):1130-1136.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[夏可嘉]'s Articles
[盛瑞隆]'s Articles
[朱英丹]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[夏可嘉]‘s Articles
[盛瑞隆]‘s Articles
[朱英丹]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2010231.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace