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学科主题: 高分子化学
题名: 聚乙二醇嵌段树枝状聚赖氨酸共聚物的合成及其基因载体研究
其他题名: Studies on the synthesis of poly(ethylene glycol)-b-dendritic poly(l-iysine)s and their application as gene carriers
作者: 崔亮 ; 李洋 ; 侯小东 ; 宫文娟 ; 徐宇虹 ; 曹阿民
通讯作者: 徐宇虹 ; 曹阿民
刊名: 化学学报
发表日期: 2007-01-01
卷: 65, 期:19, 页:2181-2186
收录类别: SCI
部门归属: 上海交通大学; 中科院上海有机所
英文摘要: New water-soluble diblock poly(ethylene glycol)-b-dendritic poly(1-lysine) with diverse dendritic generations were molecularly designed and synthesized with well-defined structures. The chemical structures of the diblock cationic copolymers were characterized by H-1 NMR. Furthermore, agarose gel electrophoresis and fluorescence titration assays were implemented to evaluate the plasmid DNA (pDNA) binding affinities of the synthesized new block copolymers, indicating higher DNA binding affinities of the diblock copolymers with 4 and 5 generation (PLL). Moreover, the dynamic light scattering was applied to characterize the polyplexes nanoparticles of the cationic carrier/pDNA, indicating the water-soluble PEG-b-dendritic PLL and pDNA could complex to form stable "core-shell" structure nanoparticles, and the biocompatible PEG shell could possibly decrease cytotoxicity of the complexed polyplexes nanoparticle during cell gene transfection. Therefore, these new structural diblock cationic macromolecules may be further developed as potential gene carriers with high efficacy.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22924
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
崔亮,李洋,侯小东,等. 聚乙二醇嵌段树枝状聚赖氨酸共聚物的合成及其基因载体研究[J]. 化学学报,2007,65(19):2181-2186.
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