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学科主题: 高分子化学
题名: Amphiphilic poly(L-lactide)-b-dendritic poly(L-lysine)s synthesized with a metal-free catalyst and new dendron initiators: Chemical preparation and characterization
其他题名: 无金属催化剂的双亲性聚乳酸-嵌段树枝状聚赖氨酸的合成
作者: Li Y(李洋) ; Li QB(李巧波) ; Li FX(李发学) ; Zhang HY(张海云) ; Jia L(贾林) ; Yu JY(俞建勇) ; Fang Q(房强) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: Biomacromolecules
发表日期: 2006
卷: 7, 期:1, 页:224-231
收录类别: SCI
部门归属: 中科院上海有机所; 东华大学
英文摘要: This study presents investigations on new approaches to novel biodegradable amphiphilic poly(L-lactide)-b-dendritic poly(L-lysine)s bearing well-defined structures. First, two new Boc-protected poly(L-lysine) dendron initiators G(2)OH 4 (generation = 2) and G(3)OH 6 (generation = 3) with hydroxyl end functional groups were efficiently derived from corresponding precursors 3 and 5 via methyl ester substitution with ethanolamine. Subsequently, two series of new diblock copolymers Of poly(L-lactide)-b-dendritic Boc-protected poly(L-lysine)s (S1-S2, S3-S4) were prepared in chloroform through ring-opening copolymerization Of poly(L-lactide)s with a metal-free catalyst of organic 4-(dimethyl amino) pyridine (DMAP) in the presence of a corresponding new poly(L-lysine) dendron initiator. Further, molecular structures of the prepared new dendron initiators as well as those of poly(L-lactide)-b-dendritic Boc-protected poly(L-lysine)s bearing different dendron blocks and PLLA lengths were examined by means of nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC), mass spectrometry (ESI-MS, MALDI-FTMS), and thermal gravimetric analysis (TGA). The results demonstrated successful formation of the synthetic precursors, functional dendron initiators, and new diblock copolymers. In addition, the very narrow molecular weight distributions (PDI = 1.10-1.14) of these poly(L-lactide)-b-dendritic Boc-protected poly(L-lysine)s further indicated their well-defined molecular structures. After the efficient Boc-deprotection for the dendron amino groups with TFA/CH2Cl2, new diblock poly(L-lactide)-b-dendritic poly(L-lysine)s bearing lipophilic PLLA and hydrophilic dendritic PLL were finally prepared. It was noteworthy that the MALDI-FTMS result showed that no appreciable intermolecular chain transesterification happened during the ROP Of L-lactide catalyzed by the DMAP. Moreover, self-assembly of these new biodegradable amphiphilic copolymers in diverse solvents were also preliminarily studied.
语种: 英语
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WOS记录号: WOS:000234549100032
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22922
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
Li Y,Li QB,Li FX,et al. Amphiphilic poly(L-lactide)-b-dendritic poly(L-lysine)s synthesized with a metal-free catalyst and new dendron initiators: Chemical preparation and characterization[J]. Biomacromolecules,2006,7(1):224-231.
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