中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 高分子材料研究室  > 期刊论文
学科主题: 高分子化学
题名: New asymmetric AB(n)-shaped amphiphilic poly(ethylene glycol)-b-[poly(L-lactide)](n) (n=2, 4, 8) bridged with dendritic ester linkages: I. Syntheses and their characterization
其他题名: 新型不对称ABn形双亲性PEG-(PLLA)n的合成与表征
作者: Li QB(李巧波) ; Li FX(李发学) ; Jia L(贾林) ; Li Y(李洋) ; Liu YC(刘艳春) ; Yu JY(俞建勇) ; Fang Q(房强) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: Biomacromolecules
发表日期: 2006
卷: 7, 期:8, 页:2377-2387
收录类别: SCI
部门归属: 中科院上海有机所; 东华大学
英文摘要: This study presents new investigations on chemical syntheses and characterization of new asymmetric AB(n)-shaped amphiphilic diblock methoxy poly(ethylene glycol)-b-[poly(L-lactide)](n), MPEG-b-(PLLA)(n) (n = 2, 4, and 8), bridged with dendritic ester linkages. First, a new series of A(OH)(n)-shaped hydroxy end-capped MPEG-(OH)(2), MPEG-(OH) 4, and MPEG-(OH) 8 bearing corresponding one- to three-generation dendritic ester moieties were efficiently derived from the starting MPEG (M-n = 2 KDa) and 2,2'- bis(hydroxymethyl)propionic acid (Bis-HMPA) via ester coupling and a facile hydroxy protection-deprotection cycle, and then, chemical structures of these functional MPEG-(OH)(n) were characterized by nuclear magnetic resonance spectrometry (NMR) and MALDI-FTMS. Subsequently, by employing these MPEG-(OH)(n) as functional macroinitiators, new asymmetric AB(n)-shaped amphiphilic MPEG-b-(PLLA)(2) S1, MPEG-b-(PLLA)(4) S2, and MPEG-b-(PLLA)(8) S3 bridged with dendritic Bis-HMPA ester linkages of L1-L3 as well as linear structural MPEG-b- PLLA references (R1-R3) were synthesized through the SnOct(2)-catalyzed ring-opening polymerization (ROP) of L-lactide at 130 degrees C in m-xylene solution, and their structures were further examined by NMR and gel permeation chromatography (GPC). It was demonstrated that the functional MPEG-(OH)(n) efficiently initiated the ROP of LLA, finally leading to successful formation of the ABn-shaped amphiphilic MPEG-b-(PLLA)(n) (n = 2, 4, and 8) with each PLLA arm weight close to 2 KDa and very narrow molecular weight distribution. Moreover, thermal history, crystallization, and spherulite morphologies were studied by means of differential scanning calorimeter (DSC), thermal gravimetric analyzer (TGA), and polarized microscope (POM) for these new structural amphiphilic S1-S3 as well as the linear R1-R3, intriguingly indicating a strong molecular architecture dependence of segmental crystallizability, spherulite morphology, and apparent crystal growth rate. Due to the favorable biodegradability and biocompatibility of the PLLA and MPEG, these results may therefore create new possibilities for these novel structural AB(n)-shaped amphiphilic MPEG-b-(PLLA)(n) as potential biomaterials.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000239723100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22912
Appears in Collections:高分子材料研究室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2006097.pdf(1898KB)----开放获取--View Download

Recommended Citation:
Li QB,Li FX,Jia L,et al. New asymmetric AB(n)-shaped amphiphilic poly(ethylene glycol)-b-[poly(L-lactide)](n) (n=2, 4, 8) bridged with dendritic ester linkages: I. Syntheses and their characterization[J]. Biomacromolecules,2006,7(8):2377-2387.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[李巧波]'s Articles
[李发学]'s Articles
[贾林]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[李巧波]‘s Articles
[李发学]‘s Articles
[贾林]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2006097.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace