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学科主题: 高分子化学
题名: New Enantiomeric Poly(lactide)-b-Poly(butylene succinate)-b-Poly(lactide)s: Syntheses, Characterization and In-situ Self-assembly
其他题名: 新型手性三嵌段共聚高分子的合成表征与原位组装
作者: Jia L(贾林) ; Yin LZ(尹林芝) ; Li Y(李洋) ; Li QB(李巧波) ; Yang J(杨晶) ; Yu JY(俞建勇) ; Shi Z(史真) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: Macromol. Biosci.
发表日期: 2005-01-01
卷: 5, 期:6, 页:526-538
收录类别: SCI
部门归属: 上海有机所; 西北大学; 东华大学
英文摘要: In-situ self-assemblies of new biodegradable triblock PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA have been investigated in acetonitrile solution. At first two series of PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA respectively denoted as the P and Q triblock copolyester series were prepared with fixed PBS block ( =6.9 KDa) and diverse enantiomeric PLLA/PDLA blocks. Further their chemical structures and thermal properties were characterized by means of titration, nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), polarimeter, wide angle X-ray diffraction (WAXD) and thermal analytical instruments. When mixing the synthesized enantiomeric copolyester pairs denoted as P1/Q1~ P8/Q8 in acetonitrile solution at 60℃, in-situ self-assemblies were found to happen for the P4/Q4 to P8/Q8 pairs bearing longer enantiomeric PLA block lengths. DSC and WAXD analysis of the self-assembled microparticles demonstrated that PLLA/PDLA racemic crystals were formed for the P5/Q5 ~ P8/Q8 systems as evidenced on their melting points over 200 ℃ and new X-ray diffraction peak detected at 2θ=11.8°. Moreover, morphological studies by scanning electron microscopy (SEM) indicated formation of disk or platelet-like microparticles. It was noted that diameters of the in-situ self-assembled microparticles decreased from 1.28-1.50??m down to 480-660 nm through tailoring the enantiomeric PLA block length, and the other factors as achiral building block, enantiomeric block length and preparation conditions were suggested to play important roles in in-situ self-assembling these enantiomeric triblock copolyesters. These results would provide a facile way to self-assemble hydrophobic biodegradable microparticles through tuning the important van der Waals interactions of stereocomplexation between two enantiomeric blocks in solution.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22906
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
Jia L,Yin LZ,Li Y,et al. New Enantiomeric Poly(lactide)-b-Poly(butylene succinate)-b-Poly(lactide)s: Syntheses, Characterization and In-situ Self-assembly[J]. Macromol. Biosci.,2005,5(6):526-538.
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