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学科主题: 高分子化学
题名: In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial osteoblasts
其他题名: 作为新型生物材料的生物降解性聚丁二酸丁二醇酯的体外评价
作者: Li HY(李海燕) ; Chang J(常江) ; Cao AM(曹阿民) ; Wang JY(王俊英)
通讯作者: 常江
刊名: Macromol. Biosci.
发表日期: 2005-01-01
卷: 5, 期:5, 页:433-440
收录类别: SCI
部门归属: 上海硅酸盐所; 上海有机所; 华东师大
英文摘要: Poly(butylene succinate) (PBSU) can be easily synthesized by condensation polymerization of the starting materials of succinic acid and butan-1,4-diol. It has good degradability and possesses excellent processability. Due to these advantages, PBSU was first evaluated in the present study for its potential application as a novel biomaterial. The in vitro biocompatibility of the PBSU was evaluated by monitoring proliferation and differentiation of osteoblasts cultured on the PBSU film substrates for different periods. The results showed that the PBSU was biocompatible as the osteoblasts could proliferate and differentiate on the PBSU plates. In addition, the hydrolytic degradation behavior of the PBSU films in the phosphate-buffered saline (PBS) was also investigated and the results suggested that the PBSU degraded in the PBS solution with the same behavior as that of the degradable poly(alpha-hydroxyesters). In addition to the biocompatibility and hydrolytic degradation, some physical properties, including hydrophilicity, and mechanical and thermal properties of the PBSU substrates, were also determined and the results revealed that the PBSU was hydrophilic and ductile with excellent processability. The biocom-patibility of the PBSU, together with the advantages of hydrolytic degradability, hydrophilicity, and excellent processability, indicated that. PBSU has the potential to be used as a biomaterial for tissue repair.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22898
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
Li HY,Chang J,Cao AM,et al. In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial osteoblasts[J]. Macromol. Biosci.,2005,5(5):433-440.
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