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学科主题: 高分子化学
题名: Novel Approach to Biodegradable Block Copolymers of ?-Caprolactone and -valerolactone Catalyzed by New Aluminum Metal Complexes
其他题名: 新型有机铝络合物催化的生物降解性嵌段共聚物的合成新方法
作者: Yang J(杨晶) ; Jia L(贾林) ; Yin LZ(尹灵芝) ; Yu JY(俞建勇) ; Shi Z(史真) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: Macromol. Biosci.
发表日期: 2004-01-01
卷: 4, 期:12, 页:1092-1104
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所高分子研究室; 西北大学; 东华大学
英文摘要: Chemical preparation of structurally well-defined biodegradable amphiphilic block copolymer is now of great interest for biomedical applications and fundamental mimetic study of biomacromolecule self-assembly. For this purpose, in this study, (R,R)-N,N’-bis-(3-tert -butylsalicylidene)-1,2-cyclohexanediamine 2 as a ligand was first synthesized from 1,2-cyclohexanediamine (DACH), and was allowed to further react with AlMe3, leading to a precursor compound 3. Then, novel five-coordinated aluminum metal complexes 4~6 and 7~8 were prepared with good yields of 80~90%, bearing various molar-mass mono-functional methoxy-poly(ethylene glycol) MPEG and di-functional poly(ethylene glycol) PEG as the alkoxy moieties, respectively. By means of nuclear magnetic resonance spectrometer (NMR), mass spectrometer (MALDI-FTMS) and Fourier transform infrared spectrometer (FTIR), the prepared new metal aluminum complexes 4~8 were characterized to be distinct chemical structures. Utilizing the synthesized metal complexes 4~8 as novel coordination polymerization catalytic templates, biodegradable amphiphilic MPEG-b-PCL, MPEG-b-PVL, PCL-b-PEG-b-PCL and PVL-b-PEG-b-PVL were synthesized with good control of molecular weight distribution via ring opening polymerization of ?-caprolactone and ?-valerolactone monomers at 100℃ in toluene. In addition, chemical and crystalline structures and thermal properties were analyzed for these block biodegradable copolymers by means of NMR, gel permeation chromatograph (GPC), wide-angle x-ray diffraction (WAXD), differential scanning calorimeter (DSC) and thermal gravimetrical analysis (TGA). It was found that melting points and crystallinities of the synthesized block copolymers strongly depended on molecular structures of the polyether and polyester building blocks. Only one glass transition stages were detected, indicating good chain/segmental miscibility between the hydrophilic MPEG/PEG and hydrophobic PCL/PVL blocks in the non-crystalline regions. Moreover, TGA analysis exhibited typical two-step decomposition profiles with the weight-loss percentages in a well agreement with block compositions on NMR calculation.mono-functional methoxy-poly(ethylene glycol) MPEG and di-functional poly(ethylene glycol) PEG as the alkoxy moieties, respectively. By means of nuclear magnetic resonance spectrometer (NMR), mass spectrometer (MALDI-FTMS) and Fourier transform infrared spectrometer (FTIR), the prepared new metal aluminum complexes 4~8 were characterized to be distinct chemical structures. Utilizing the synthesized metal complexes 4~8 as novel coordination polymerization catalytic templates, biodegradable amphiphilic MPEG-b-PCL, MPEG-b-PVL, PCL-b-PEG-b-PCL and PVL-b-PEG-b-PVL were synthesized with good control of tone monomers at 100℃ in toluene. In addition, chemical and crystalline structures and thermal properties were analyzed for these
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22890
Appears in Collections:高分子材料研究室_期刊论文

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Recommended Citation:
Yang J,Jia L,Yin LZ,et al. Novel Approach to Biodegradable Block Copolymers of ?-Caprolactone and -valerolactone Catalyzed by New Aluminum Metal Complexes[J]. Macromol. Biosci.,2004,4(12):1092-1104.
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