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Studies on the physicochemical properties, structure and antitumor activity of an oligosaccharide homologue SnS-2 from the root of Scrophularia ningpoensis Hemsl.
其他题名玄参寡糖SnS-2的物理性质, 结构和抗肿瘤活性的研究
Deng JE(邓军娥); Zhang J(张健); Chen XM(陈晓明); Ke W(柯炜); Tian GY(田庚元)
2004
发表期刊Chin. J. Chem.
ISSN1001-604X
卷号22期号:5页码:492-497
摘要An oligosaccharide homologue named SnS-2 was isolated from the root of Scrophularia ningpoensis Hemsl. SnS-2 was purified by means of gel-permeation chromatography and ion-exchange chromatography. Its physicochemical properties, including carbohydrate content and molecular weight were determined. The structure of SnS-2 was elucidated by chemical methods along with H-1 and C-13 NMR spectroscopy, including two-dimensional DQCOSY and H-detected H-1, C-13 HMQC experiments. These results show that SnS-2 possesses a backbone consisting of terminal alpha-Galp-(1-->, alpha-Galp-(1-->6), alpha-Glcp-(1-->6) and nonreducing end beta-Fruf-(2-->. The bioactive assay showed that it could inhibit the growth of Lewis pulmonary carcinoma implanted in mice.
学科领域生命有机化学
部门归属中国科学院上海有机化学研究所生命有机化学实验室
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收录类别SCI
语种英语
WOS记录号WOS:000221498700019
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/22756
专题生命有机化学国家重点实验室
通讯作者Tian GY(田庚元)
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GB/T 7714
Deng JE,Zhang J,Chen XM,et al. Studies on the physicochemical properties, structure and antitumor activity of an oligosaccharide homologue SnS-2 from the root of Scrophularia ningpoensis Hemsl.[J]. Chin. J. Chem.,2004,22(5):492-497.
APA 邓军娥,张健,陈晓明,柯炜,&田庚元.(2004).Studies on the physicochemical properties, structure and antitumor activity of an oligosaccharide homologue SnS-2 from the root of Scrophularia ningpoensis Hemsl..Chin. J. Chem.,22(5),492-497.
MLA 邓军娥,et al."Studies on the physicochemical properties, structure and antitumor activity of an oligosaccharide homologue SnS-2 from the root of Scrophularia ningpoensis Hemsl.".Chin. J. Chem. 22.5(2004):492-497.
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