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学科主题: 生命有机化学
题名: Studies on the physicochemical properties, structure and antitumor activity of an oligosaccharide homologue SnS-2 from the root of Scrophularia ningpoensis Hemsl.
其他题名: 玄参寡糖SnS-2的物理性质, 结构和抗肿瘤活性的研究
作者: Deng JE(邓军娥) ; Zhang J(张健) ; Chen XM(陈晓明) ; Ke W(柯炜) ; Tian GY(田庚元)
通讯作者: 田庚元
刊名: Chin. J. Chem.
发表日期: 2004
卷: 22, 期:5, 页:492-497
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: An oligosaccharide homologue named SnS-2 was isolated from the root of Scrophularia ningpoensis Hemsl. SnS-2 was purified by means of gel-permeation chromatography and ion-exchange chromatography. Its physicochemical properties, including carbohydrate content and molecular weight were determined. The structure of SnS-2 was elucidated by chemical methods along with H-1 and C-13 NMR spectroscopy, including two-dimensional DQCOSY and H-detected H-1, C-13 HMQC experiments. These results show that SnS-2 possesses a backbone consisting of terminal alpha-Galp-(1-->, alpha-Galp-(1-->6), alpha-Glcp-(1-->6) and nonreducing end beta-Fruf-(2-->. The bioactive assay showed that it could inhibit the growth of Lewis pulmonary carcinoma implanted in mice.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000221498700019
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22756
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Deng JE,Zhang J,Chen XM,et al. Studies on the physicochemical properties, structure and antitumor activity of an oligosaccharide homologue SnS-2 from the root of Scrophularia ningpoensis Hemsl.[J]. Chin. J. Chem.,2004,22(5):492-497.
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