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学科主题: 生命有机化学
题名: 羟乙基化牛膝多糖的合成及其活性研究
其他题名: Studies on synthesis, structure and bioactivity of hydroxyethylated abps
作者: 张健 ; 田庚元
通讯作者: 田庚元
刊名: 化学学报
发表日期: 2003-01-01T00:00:00Z
卷: 61, 期:10, 页:1692-1696
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
摘要: 以环氧乙烷为羟以及试剂,在碱性水溶液中,对牛膝多糖(Abps)进行羟乙基化, 经过丙酮沉淀、膜分离 Sephadex G-25柱层析等分离方法得到羟乙基化牛膝多糖(Abps-HE)纯品, 检测其理化性质, 并通过甲基化、GC-MS分析,初步却增糖链中羟以及主要区带在葡萄糖6位和果糖的1位和6位上。药理实验表明,羟乙基化牛膝多糖对何Lewis肺癌小鼠NK活性具有一定促进作用。
英文摘要: Achyranthes bidentata polysaccharide (Achyranthan, Abps) was hydroxyethylated by ethylene oxide in aqueous NaOH. The crude produt was purified by acetone precipitation, dialysis, and Sephadex G-25 column chromatography to give hydroxyethylated Abps (Abps-HE), which was identified by some physicochemical properties By the methylation method and GC-MS analysis, it is concluded that the hydroxyethyl groups are mainly substituted on 6-position of the glucopyranose and fructofuranose of the sugar backbone. The product possesses antiumor activity and improves NK cell activity in Lewis lung cancer mice.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22744
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
张健,田庚元. 羟乙基化牛膝多糖的合成及其活性研究[J]. 化学学报,2003,61(10):1692-1696.
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