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学科主题: 生命有机化学
题名: 羧甲基牛膝多糖的制备、结构及生物活性研究
其他题名: Studies on the preparation, structure and bioactivity of CM-AbPS
作者: 邓乐华 ; 田庚元
通讯作者: 田庚元
刊名: 化学学报
发表日期: 2002-01-01
卷: 60, 期:11, 页:2049-2055
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
摘要: 在NaOH水溶液中以C1CH^2COOH为羧甲基化试剂,对牛膝多糖(AbPS)进行了羧甲基化,粗产物经DEAE-Cellulose及Sephadex G-25两次柱层析纯化,得到羧甲基牛膝多糖(CM-AcPS)纯品,经高效液相法(HPLC)及毛细管电泳法(CE)检测表明具有较好的均一性.并通过样品甲基化和GC—MS分析,对羧甲基牛膝多糖糖链中羧甲基的分布进行了研究,结果表明羧甲基牛膝多糖中羧甲基主要取代在糖链中呋喃果糖的4-位上.该产物具有抗肿瘤活性.
英文摘要: Achyranthes bidentata polysaccharides (AbPS) was carboxymethylated by ClCH^2COOH in aqueous NaOH and the crude product was purified by successive DEAE-Cellulose and sephadex G25- column chromatography to yield homogeneous carboxymethylated product (CM-AbPS), which was detected by high performance liquid chromatography(HPLC) and capillary electrophoresis (CE). By the methylation method and GC-MS analysis, we studied the distribution of carboxymethyl groups in the sugar backbone of CM_AbPS and conclude that the carboxymethyl groups mainly substitute on 4-position of the fructofuranose of the sugar backbone. The product has anti-tumor activity.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22736
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
邓乐华,田庚元. 羧甲基牛膝多糖的制备、结构及生物活性研究[J]. 化学学报,2002,60(11):2049-2055.
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