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学科主题: 生命有机化学
题名: Studies on synthesis and antitumor activity of phosphorylated achyranthes bidentata polysac charideP-AbPS)
其他题名: 磷酸化牛膝多糖的合成研究及抗肿瘤活性
作者: Chen XM(陈晓明) ; Zhang J(张健) ; Tian GY(田庚元)
通讯作者: 田庚元
刊名: Chin. J. Chem.
发表日期: 2002-01-01
卷: 20, 期:11, 页:1406-1410
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: The synthesis of phosphorylated achyranthes bidentata polysaccharide (P-AbPS) was reported based on different strategies. The P-AbPS with high degree of substitution (D.S.>0.5) was obtained when phosphorus oxychloride (POCl^3) was used as a phosphorylating agent and trimethyl phosphate-pyridine or dimethyl formamide was used as solvent. The influences of different solvents and reaction conditions were discussed. The pharmacology assay shows that P-AbPs possesses antitumor activity against sarcoma 180 and lewis lung cancer in mice.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22732
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Chen XM,Zhang J,Tian GY. Studies on synthesis and antitumor activity of phosphorylated achyranthes bidentata polysac charideP-AbPS)[J]. Chin. J. Chem.,2002,20(11):1406-1410.
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