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学科主题: 生命有机化学
题名: Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.
其他题名: 枸杞子糖缀合物的化学和免疫调节机理的研究
作者: Peng XM(彭雪梅) ; Huang LJ(黄琳娟) ; Qi CH(齐春会) ; Zhang YX(张永详) ; Tian GY(田庚元)
通讯作者: 田庚元
刊名: Chin. J. Chem.
发表日期: 2001
卷: 19, 期:12, 页:1190-1197
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家重点实验室
英文摘要: The detailed structure of an O-glycan derived from the fruit of Lycium barbarum L. Was elucidatd based on glycosidic linkange analysis, complete and partial acid hydrolysis, ~1H-NMR and ~13C NMR spectroscopy. According to the experiments, the carbohydrate was in the form of polysacchride (arabinogalactan) chains with highly branched 3,4--galactans and terminal arabinfuranosyl substituents. The immuno-modulating mechanism of glycoconjugate and its glycan were investiganted using tritium thymidine incorporation assay, flow cytometry assay and electrophoretical mobility shift assay (EMSA). The results suggested that the immunoactive compounents of the fruit of lycium barbarum L.could enhance the splenocyte proliferation in normal mice and the effects of glycan chain were stronger than those of glycoconjugate. The target cell was most likely to be B-lymphocyte, on which existed receptor binding site acting with the glycan. In addition, the immuno-stimulatory effect of glycoconjugate (LbGp4) and its glycan (LbGp4-OL)was associated with activating the expression of nuclear factor kB(NF-kB) and activator protein 1 (AP-1)
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000172869400005
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22728
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Peng XM,Huang LJ,Qi CH,et al. Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.[J]. Chin. J. Chem.,2001,19(12):1190-1197.
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