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Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.
其他题名枸杞子糖缀合物的化学和免疫调节机理的研究
Peng XM(彭雪梅); Huang LJ(黄琳娟); Qi CH(齐春会); Zhang YX(张永详); Tian GY(田庚元)
2001
发表期刊Chin. J. Chem.
ISSN1001-604X
卷号19期号:12页码:1190-1197
摘要The detailed structure of an O-glycan derived from the fruit of Lycium barbarum L. Was elucidatd based on glycosidic linkange analysis, complete and partial acid hydrolysis, ~1H-NMR and ~13C NMR spectroscopy. According to the experiments, the carbohydrate was in the form of polysacchride (arabinogalactan) chains with highly branched 3,4--galactans and terminal arabinfuranosyl substituents. The immuno-modulating mechanism of glycoconjugate and its glycan were investiganted using tritium thymidine incorporation assay, flow cytometry assay and electrophoretical mobility shift assay (EMSA). The results suggested that the immunoactive compounents of the fruit of lycium barbarum L.could enhance the splenocyte proliferation in normal mice and the effects of glycan chain were stronger than those of glycoconjugate. The target cell was most likely to be B-lymphocyte, on which existed receptor binding site acting with the glycan. In addition, the immuno-stimulatory effect of glycoconjugate (LbGp4) and its glycan (LbGp4-OL)was associated with activating the expression of nuclear factor kB(NF-kB) and activator protein 1 (AP-1)
学科领域生命有机化学
部门归属中国科学院上海有机化学研究所生命有机国家重点实验室
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收录类别SCI
语种英语
WOS记录号WOS:000172869400005
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被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/22728
专题生命有机化学国家重点实验室
通讯作者Tian GY(田庚元)
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GB/T 7714
Peng XM,Huang LJ,Qi CH,et al. Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.[J]. Chin. J. Chem.,2001,19(12):1190-1197.
APA 彭雪梅,黄琳娟,齐春会,张永详,&田庚元.(2001).Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L..Chin. J. Chem.,19(12),1190-1197.
MLA 彭雪梅,et al."Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.".Chin. J. Chem. 19.12(2001):1190-1197.
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