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学科主题: 生命有机化学 ; 计算机化学与化学信息学
题名: 基于计算机模拟的拟糖三肽的设计与合成
其他题名: Design and synthesis of glyco-replica tripeptides based on molecular modeling
作者: 单丽 ; 徐杰诚 ; 夏宗芗 ; 李家大
通讯作者: 徐杰诚
刊名: 化学学报
发表日期: 2004-01-01
卷: 62, 期:2, 页:199-203
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: Based on the results of phage display, the interactions between three glyco-replica peptides and glucoamylase were investigated by molecular dynamics simulation. The results of the computer modeling showed that the basic amino acid residue at N-terminus of each oligopeptide was bound to the active sites of the enzyme. Three tripeptides were designed using molecular modeling and synthesized by liquid phase synthesis method, which are to be used to prepare the crystals of the complexes with glucoamylase or alpha-amylase.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22648
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
单丽,徐杰诚,夏宗芗,等. 基于计算机模拟的拟糖三肽的设计与合成[J]. 化学学报,2004,62(2):199-203.
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