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学科主题: 生命有机化学
题名: The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design
其他题名: 根据合理分子设计的氧正离子型高效缩合剂的发展
作者: Li P(李鹏) ; Xu JC(徐杰诚)
通讯作者: 徐杰诚
刊名: J. Pept. Res.
发表日期: 2001
卷: 58, 期:2, 页:129-139
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: Novel and highly efficient immonium-, pyridinium-and thiazolium-type peptide coupling reagents, such as BOMI, BDMP, BPMP,BEP,FEP,BEPH,FEPH and BEMT, were developed by rational modifying of the molecular structures of commonly used uronium-type reagents. The high efficiency of these onium salts has been evaluated and proven by model reaction tests and the successful synthesis of various oligopeptides and biologically active peptides, both in solution and in the solid-phase, for example Leu-enkephalin, the pentapeptide moiety of Dolastatin 15 and the immunosuppressive undecapeptide cyclosporin O. Based upon these results, the relationship between the molecular structure and the capability of oniumtype peptide coupling reagents was studied. A preliminary guideline for the molecular design of onium-type coupling reagents was developed.
语种: 英语
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WOS记录号: WOS:000170471700004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22644
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Li P,Xu JC. The development of highly efficient onium-type peptide coupling reagents based upon rational molecular design[J]. J. Pept. Res.,2001,58(2):129-139.
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