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学科主题: 生命有机化学
题名: Synthesis of chiral peptide nucleic acids using fmoc chemistry
其他题名: 用Fmoc 化学合成手性肽核酸
作者: Wu Y(武芸) ; Xu JC(徐杰诚)
通讯作者: 徐杰诚
刊名: Tetrahedron
发表日期: 2001
卷: 57, 期:38, 页:8107-8113
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家重点实验室
英文摘要: A fmoc-based synthesis of chiral PNAs is described. Chiral monomer backbones were efficiently prepared by reductive amination of N-fmoc-protected L,D-alaninals with glycine esters and the subsequent acylation of free amines with thymine-1-ylacetic acid. The dimer derivative of L-amino acid was prepared in solution. Finally, a chiral decamer was obtained by a solid phase strategy using a succinyl-linked support.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000171210700012
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22640
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Wu Y,Xu JC. Synthesis of chiral peptide nucleic acids using fmoc chemistry[J]. Tetrahedron,2001,57(38):8107-8113.
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