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学科主题: 生命有机化学
题名: Novel immonium type peptide coupling reagent: 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP)
其他题名: 新型亚胺盐类型多肽缩合剂:5-(1H-苯骈三唑氧基-3,4-二氢-1-甲基2H-吡咯盐六氯化锑盐
作者: Li P(李鹏) ; Xu JC(徐杰诚)
通讯作者: 徐杰诚
刊名: Chin. J. Chem.
发表日期: 2000-01-01
卷: 18, 期:1, 页:85-93
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: A novel immonium type coupling reagent, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP) has been designed, synthesized and utilized to synthesize oligopeptides and bilogically active peptide both in solution and solid phase with satisfactory yield, low racemization and fast reaction rate. The estimation of racemization and the influence of several reaction parameters were studied by HPLC method using the model reaction: Z-Gly-Phe-OH+Val-Ome.HCl→Z-Gly-D/L-Phe-Val-Ome. It was shown that the reactivity of BDMP was much higher fand the racemization was much lower than those of HOBt-based `onium` reagents, even though its analogues BOMI. To further verified the effectiveness of BDMP< Leu-enkephalin was synthesized both in solution and solid phase using BDMP as coupling reagent. The proposed mechanism was also specu-lated.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22618
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Li P,Xu JC. Novel immonium type peptide coupling reagent: 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl 2H-pyrrolium hexachloroantimonate (BDMP)[J]. Chin. J. Chem.,2000,18(1):85-93.
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