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学科主题: 生命有机化学
题名: A novel thiazolium type peptide coupling reagent for hindered amino acids.
其他题名: 新型用于有空间的氨基酸的多肽缩合剂
作者: Li P(李鹏) ; Xu JC(徐杰诚)
通讯作者: 徐杰诚
刊名: Tetrahedron Lett.
发表日期: 1999-01-01
卷: 40, 页:8301-8304
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: A highly efficent coupling reagent, 2-bromo-3-ethyl-4-methyl thiazolium terafluoroborate (BEMT), was designed, synthesized and successfully applied to the synthesis of oligopeptides containing N-alkyl or α-C-dialkyl amino acids. Its effciency was evaluated by HPLC and ^1H NMR methods, and demonstrated by synthesis of a number of N-methyl-rich peptide segments with good yields and negligible recemization. The mechanism of coupling was studied by HPLC, ^1H NMR and IR monitoring; it is proposed that labile (acyloxy) thiazolium salts and N_Protected amino acid bromides were the major active intermediates with concomitant formation of N-ethyl-4-methyl thiazolidones and a small amount of oxazolones and N-protected amino acid anhydrides.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22608
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Li P,Xu JC. A novel thiazolium type peptide coupling reagent for hindered amino acids.[J]. Tetrahedron Lett.,1999,40:8301-8304.
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