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A novel thiazolium type peptide coupling reagent for hindered amino acids.
其他题名新型用于有空间的氨基酸的多肽缩合剂
Li P(李鹏); Xu JC(徐杰诚)
1999
发表期刊Tetrahedron Lett.
ISSN0040-4039
卷号40页码:8301-8304
摘要A highly efficent coupling reagent, 2-bromo-3-ethyl-4-methyl thiazolium terafluoroborate (BEMT), was designed, synthesized and successfully applied to the synthesis of oligopeptides containing N-alkyl or α-C-dialkyl amino acids. Its effciency was evaluated by HPLC and ^1H NMR methods, and demonstrated by synthesis of a number of N-methyl-rich peptide segments with good yields and negligible recemization. The mechanism of coupling was studied by HPLC, ^1H NMR and IR monitoring; it is proposed that labile (acyloxy) thiazolium salts and N_Protected amino acid bromides were the major active intermediates with concomitant formation of N-ethyl-4-methyl thiazolidones and a small amount of oxazolones and N-protected amino acid anhydrides.
学科领域生命有机化学
部门归属中国科学院上海有机化学研究所
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收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/22608
专题上海有机化学研究所
通讯作者Xu JC(徐杰诚)
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GB/T 7714
Li P,Xu JC. A novel thiazolium type peptide coupling reagent for hindered amino acids.[J]. Tetrahedron Lett.,1999,40:8301-8304.
APA 李鹏,&徐杰诚.(1999).A novel thiazolium type peptide coupling reagent for hindered amino acids..Tetrahedron Lett.,40,8301-8304.
MLA 李鹏,et al."A novel thiazolium type peptide coupling reagent for hindered amino acids.".Tetrahedron Lett. 40(1999):8301-8304.
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