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学科主题: 金属有机化学
题名: Asymmetric Friedel-Crafts Alkylation of Indoles: The Control of Enantio-and Regioselectivity
其他题名: 吲哚的不对称傅克烷基化: 对映体选择性与区域选择性的控制
作者: Ceng M(曾蜜) ; You SL(游书力)
通讯作者: 游书力
刊名: Synlett
发表日期: 2010
期: 9, 页:1289-1301
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: The asymmetric Friedel-Crafts reaction of indoles is a synthetic methodology that enables direct access to the enantiopure indole derivatives. In this review, work mainly carried out by You and his co-workers on the regio- and enantioselective synthesis of indole derivatives will be discussed. Chiral Bronsted acids or iridium complexes promote highly enantioselective Friedel-Crafts reactions of indoles and 4,7-dihydroindoles starting with various electrophilic reagents, such as imines, N-tosyl-substituted amines, beta,gamma-unsaturated a-keto esters, nitro-substituted olefins, aldehydes, and allyl carbonates. These methodologies can be used to readily prepare diverse enantioenriched indoles, such as indol-3-ylmethanamines, indol-2-ylmethanamines, unsymmetrical arylbis(indol-3-yl)methanes, 9-indol-3-ylfluorenes, tetrahydropyrano[3,4-b]indoles, tetrahydro-gamma-carbolines, and tetrahydro-beta-carbolines.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000278408800001
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/22520
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ceng M,You SL. Asymmetric Friedel-Crafts Alkylation of Indoles: The Control of Enantio-and Regioselectivity[J]. Synlett,2010(9):1289-1301.
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