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学科主题: 生命有机化学
题名: Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis
其他题名: 新颖青藤碱衍生物1032可以改善提升EAE动物模型的免疫抑制
作者: YAN LINGCHEN ; BI ENGUANG ; LOU YANGTONG ; WU XIAODONG ; LIU ZHIDUO ; ZHOU JIA ; WANG YUAN ; MA ZHAO ; LIN GUOMEI ; SUN SHUHUI ; BIAN CHAO ; CHEN AIZHONG ; Yao ZJ(姚祝军) ; Sun B(孙兵)
通讯作者: 姚祝军 ; 孙兵
刊名: Biochem. Biophys. Res. Commun.
发表日期: 2010
卷: 391, 期:1, 页:1093-1098
收录类别: SCI
部门归属: 中国科学院上海生命科学研究院; 中国科学院上海有机化学研究所; 复旦大学
英文摘要: Sinomenine (SIN) is an alkaloid isolated from the Chinese medicinal plant Sinomenium acutum. It is widely used as an immunosuppressive drug for treating autoimmune diseases. Due to its poor efficiency, the large-dose treatment presents some side effects and limits its further applications. In this study, we used chemical modification to improve the therapeutic effect of SIN in vitro and in vivo. A new derivative of sinomenine, named 1032, demonstrates significantly improved immunosuppressive activity over that of its parent natural compound (SIN). In an experimental autoimmune encephalomyelitis (EAE) model, 1032 significantly reduced encephalitogenic T cell responses and induced amelioration of EAE, which outcome was related to its selective inhibitory effect on the production of IL-17. By contrast, SIN treatment only led to a moderate alleviation of EAE severity and the expression level of IL-17 was not significantly reduced. Furthermore, 1032 exhibited suppression of Th17, but not Treg, cell differentiation, a result probably related to its inhibitory effect on I kappa B-alpha. degradation as well as on IL-6 and TNF-alpha secretion in BMDCs. We speculate that 1032 as a novel anti-inflammatory agent may target DC to block IL-6 production, which in turn would terminate Th17 cell development. Thus, SIN derivative 1032 presents considerable potential in new drug development for treating autoimmune and inflammatory disease. (C) 2009 Elsevier Inc. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000273624500193
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21147
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
YAN LINGCHEN,BI ENGUANG,LOU YANGTONG,et al. Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis[J]. Biochem. Biophys. Res. Commun.,2010,391(1):1093-1098.
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