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学科主题: 生命有机化学
题名: Synthesis of the cyclic nonapeptide of chlorofusin using a convergent [3+3+3]-fragment coupling strategy
其他题名: Chlorofusin中环九肽的汇聚式[3+3+3]-合成
作者: WANG YANLI ; QIAN WENJIAN ; WEI WANGUO ; ZHANG YUE ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Tetrahedron
发表日期: 2010
卷: 66, 期:19, 页:3427-3432
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 河北科技大学
英文摘要: A [3+3+3]-fragment coupling strategy was successfully applied in the synthesis of the nonacyclopeptide of chlorofusin, a potent natural antagonist against p53-MDM2 interactions. The accomplished convergent synthesis includes parallel syntheses of three tripeptides and their sequential assembly, and macrocyclization of the linear precursor to the required 27-membered nonacyclopeptide. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000277967400006
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21139
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
WANG YANLI,QIAN WENJIAN,WEI WANGUO,et al. Synthesis of the cyclic nonapeptide of chlorofusin using a convergent [3+3+3]-fragment coupling strategy[J]. Tetrahedron,2010,66(19):3427-3432.
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