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学科主题: 生命有机化学
题名: Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone
其他题名: 群蛀虫内酯C2-C10片断的立体选性合成
作者: Zhou ZZ(周佐中) ; Suo D(索栋) ; Yang ZY(杨震宇) ; Chen L(陈琳) ; Hu TS(胡泰山) ; Yao ZJ(姚祝军)
通讯作者: 陈琳 ; 姚祝军
刊名: Chin. J. Chem.
发表日期: 2009
卷: 27, 期:1, 页:135-140
收录类别: SCI
部门归属: 云南民族大学; 上海有机所
英文摘要: A stereoselective synthesis of all functionalized C2-C10 fragment 13 of the antitumor marine natural product clavulactone was accomplished. starting from the commercially available 3-methylglutaric acid anhydride. Desymmetrization of 3-methylglutaric acid anhydride with (S)-alpha-phenylethanamine was successfully employed as a key step to embed the isolated C8-methyl group with the correct absolute configuration (99% de). The C3-C4 cis-double bond was stereospecifically furnished by an RCM (ring-closing metathesis) approach. Fragment 13 contains all preset functionalities and will be a useful precursor for the convergent total synthesis of clavulactone.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000264039400023
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21133
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Zhou ZZ,Suo D,Yang ZY,et al. Stereoselective Synthesis of the Functionalized C2-C10 Fragment of Clavulactone[J]. Chin. J. Chem.,2009,27(1):135-140.
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