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学科主题: 生命有机化学
题名: Efficient Synthesis of 4-Amido-N-5-acetyl-4-deoxyneuraminic Acid and Its Application to the C-4 Modification of Sialic Acids
其他题名: 4-氨基4-脱氧唾液酸的立体选择性合成及其应用
作者: Gao ZX(高正曦) ; Wang M(王蒙) ; Wang SZ(王少仲) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Org. Lett.
发表日期: 2009
卷: 11, 期:16, 页:3678-3681
收录类别: SCI
部门归属: 上海有机所; 南京大学
英文摘要: A straightforward synthesis of 4-amido-N-6-acetyl-4-deoxyneuraminic acid, a key precursor to various 4-amidoneuraminic acid analogues, has been achieved using a highly regioselective and diastereoselective [3 + 2]-cycloaddition of D-mannose-derived nitrone with methyl acrylate. Advantages of this newly developed synthesis include the use of economically available materials and reagents, the ease of operations and the excellent control of stereochemistry, as well as the convenience in application to the C-4 modifications of sialic acids.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000268796700040
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21131
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Gao ZX,Wang M,Wang SZ,et al. Efficient Synthesis of 4-Amido-N-5-acetyl-4-deoxyneuraminic Acid and Its Application to the C-4 Modification of Sialic Acids[J]. Org. Lett.,2009,11(16):3678-3681.
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