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学科主题: 生命有机化学
题名: Effects of generated trans-arachidonic acids on retinal capillary during nitrative stress in diabetic rats
其他题名: 硝化应激中反式花生四烯酸聚集对糖尿病大鼠视网膜微血管的影响
作者: Xu L(许琳) ; Xun GL(寻国良) ; Yao ZJ(姚祝军) ; Liu YM(刘玉敏) ; Qiu YP(邱云平) ; Liu K(刘堃) ; Zhu DQ(朱冬青) ; Gu Q(顾青) ; Xu X(许迅) ; He ZP(何志平)
通讯作者: 许迅
刊名: Ophthalmologica
发表日期: 2008
卷: 222, 期:1, 页:37-41
收录类别: SCI
部门归属: 上海有机所; 上海交通大学附属第一人民医院眼科; Hong Kong Eye Associates
英文摘要: Purpose: To investigate whether the trans-arachidonic acids (TAAs) change in diabetic conditions and the effect on capillary cells and its possible mechanism. Methods: Diabetes was induced by intraperitoneal injection of streptozotocin at 60 mg kg(-1) body weight. The amount of TAAs and arachidonic acid (AA) in serum of diabetic rats was measured by the gas chromatography and mass spectrometry method and the ratio of the peak area of TAAs to AA with a selected ion of 79 was estimated by group t test. The expression level of thrombospondin-1 (TSP-1) in the retina was examined by Western blot. The pericyte apoptotic index was investigated by flow cytometry. Result: The ratio of TAAs to AA significantly increased in serum at the time points of 8, 12 and 16 weeks after streptozotocin induction (p < 0.05). The expression of TSP-1 in the retina of diabetic rats elevated with longer duration of diabetes (checking the time points of 2-, 4-, 8-, 12- and 16-week diabetic rats). The expression of TSP-1 tended to be physiologically elevated in relation to age but less significantly than in the diabetic group. TAAs could not induce the apoptosis of retinal pericytes (p > 0.05). Conclusion: TAAs were generated associated with nitrative stress in diabetic rats and a possible mechanism of microvascular injury exits in diabetic conditions. Copyright (C) 2007 S. Karger AG, Basel.
语种: 英语
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WOS记录号: WOS:000251835400008
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21119
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Xu L,Xun GL,Yao ZJ,et al. Effects of generated trans-arachidonic acids on retinal capillary during nitrative stress in diabetic rats[J]. Ophthalmologica,2008,222(1):37-41.
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