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学科主题: 生命有机化学
题名: Site-Specific Fluorescent Labeling Approaches for Naringenin, an Essential Flavonone in Plant Nitrogen-Fixation Signaling Pathways
其他题名: 植物固氮信号分子柚皮素位置专一性的荧光标记
作者: Chen L(陈磊) ; Li FQ(李风庆) ; Hou BH(侯碧和) ; Hong GF(洪国藩) ; Yao ZJ(姚祝军)
通讯作者: 洪国藩 ; 姚祝军
刊名: J. Org. Chem.
发表日期: 2008
卷: 73, 期:21, 页:8279-8285
收录类别: SCI
部门归属: 上海生命科学院生物化学与细胞生物所; 上海有机化学研究所
英文摘要: In search of an appropriate position for the fluorescent labeling. six chemically available positions of the flavonone core of naringenin have been examined. A number of azido-containing naringenin derivatives were accordingly prepared in various site-specific fashions. and the Mild CU(I)-catalyzed Huisgen 1-3-dipolar cycloaddition successfully served as the common "Click" labeling tool in the final steps. Oil the basis of the biological activities of the first batch of labeled compounds, further optimization at the C-6 position of naringenin finally afforded naringenin-flu (27). which acquired 20% of the potency of naringenin and presented good optical properties. Entry of naringenin-flu into living Rhizobium Cells was demonstrated by in vitro fluorescent imaging experiments.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000260533300018
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21105
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Chen L,Li FQ,Hou BH,et al. Site-Specific Fluorescent Labeling Approaches for Naringenin, an Essential Flavonone in Plant Nitrogen-Fixation Signaling Pathways[J]. J. Org. Chem.,2008,73(21):8279-8285.
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