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学科主题: 生命有机化学
题名: Total synthesis, assignment of absolute stereochemistry, and structural revision of chlorofusin
其他题名: Chlorofusin的全合成、绝对构型归属与结构修正
作者: Qian WJ(钱文建) ; Wei WG(魏万国) ; Zhang YX(张永霞) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: J. Am. Chem. Soc.
发表日期: 2007
卷: 129, 期:20, 页:6400-6401
收录类别: SCI
部门归属: 上海有机化学研究所
英文摘要: The first total synthesis of chlorofusin was accomplished in a convergent fashion. With all four unambiguous diastereomeric model chromophores as references, the absolute stereochemistry of the chlorofusin chromophore was determined and revised to be (4S,8R,9S) by H-1 NMR studies and asymmetric synthesis. This allows the complete structure of natural chlorofusin to be assigned for the first time. Enantioselective copper-mediated oxidation of 4, mild coupling of azaphilone 2 with the free amine-bearing cyclopeptide 3, and a one-pot three-step protocol for the final spiro-aminal formation were successfully achieved with high efficiency to yield the correct stereochemical product 1a.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000246535300028
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21095
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Qian WJ,Wei WG,Zhang YX,et al. Total synthesis, assignment of absolute stereochemistry, and structural revision of chlorofusin[J]. J. Am. Chem. Soc.,2007,129(20):6400-6401.
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