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学科主题: 生命有机化学
题名: Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells
其他题名: 末端为内酰胺的番荔枝内酯类似物及其对癌细胞的细胞
作者: Liu HX(刘海侠) ; Huang GR(黄国瑞) ; Zhang HM(张焕明) ; Wu JR(吴家睿) ; Yao ZJ(姚祝军)
通讯作者: 吴家睿 ; 姚祝军
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2007
卷: 17, 期:12, 页:3426-3430
收录类别: SCI
部门归属: 上海有机化学研究所; 上海生化细胞所
英文摘要: Annonaceous acetogenins are a large class of naturally occurring polyketides exhibiting potent anticancer activities. Based on our previous discovery of AA005, a multi-ether mimic of natural acetogenins having potent antitumor activities and significant selectivity between normal cells and cancer cells, a new series of mimics containing a terminal lactam were designed, synthesized and evaluated. Bioactivity study against cancer cells shows that the N-methylated lactam-containing compounds 3, 4, and 5 exhibit comparable potencies to that of AA005, as well as the similar selectivity to cancer cells. Hydrocarbon-length effects of N-alkyl were further explored through synthesizing derivatives 24-26, and application of this derivation protocol to the fluorescent labeling was also investigated. (c) 2007 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000247496200036
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21091
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Liu HX,Huang GR,Zhang HM,et al. Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells[J]. Bioorg. Med. Chem. Lett.,2007,17(12):3426-3430.
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