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Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells
其他题名末端为内酰胺的番荔枝内酯类似物及其对癌细胞的细胞
Liu HX(刘海侠); Huang GR(黄国瑞); Zhang HM(张焕明); Wu JR(吴家睿); Yao ZJ(姚祝军)
2007
发表期刊Bioorg. Med. Chem. Lett.
ISSN0960-894X
卷号17期号:12页码:3426-3430
摘要Annonaceous acetogenins are a large class of naturally occurring polyketides exhibiting potent anticancer activities. Based on our previous discovery of AA005, a multi-ether mimic of natural acetogenins having potent antitumor activities and significant selectivity between normal cells and cancer cells, a new series of mimics containing a terminal lactam were designed, synthesized and evaluated. Bioactivity study against cancer cells shows that the N-methylated lactam-containing compounds 3, 4, and 5 exhibit comparable potencies to that of AA005, as well as the similar selectivity to cancer cells. Hydrocarbon-length effects of N-alkyl were further explored through synthesizing derivatives 24-26, and application of this derivation protocol to the fluorescent labeling was also investigated. (c) 2007 Elsevier Ltd. All rights reserved.
学科领域生命有机化学
部门归属上海有机化学研究所; 上海生化细胞所
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收录类别SCI
语种英语
WOS记录号WOS:000247496200036
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/21091
专题生命有机化学国家重点实验室
通讯作者Wu JR(吴家睿); Yao ZJ(姚祝军)
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Liu HX,Huang GR,Zhang HM,et al. Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells[J]. Bioorg. Med. Chem. Lett.,2007,17(12):3426-3430.
APA 刘海侠,黄国瑞,张焕明,吴家睿,&姚祝军.(2007).Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells.Bioorg. Med. Chem. Lett.,17(12),3426-3430.
MLA 刘海侠,et al."Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells".Bioorg. Med. Chem. Lett. 17.12(2007):3426-3430.
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