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学科主题: 生命有机化学
题名: Ring-closing metathesis-based synthesis of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxycyclohex-1-ene-carboxylic acid ethyl ester: A functionalized cycloalkene skeleton of GS4104
其他题名: RCM法合成达菲的主体结构
作者: Cong X(丛欣) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: J. Org. Chem.
发表日期: 2006
卷: 71, 期:14, 页:5365-5368
收录类别: SCI
部门归属: 中科院上海有机所
英文摘要: (3R,4R,5S)-4-Acetylamino-5-amino-3-hydroxy-cyclohex-1-ene-carboxylic acid ethyl ester, a functionalized cyclohexene skeleton of GS4104, was diastereoselectively synthesized. A major advantage of this synthesis is the use of readily available L-serine to replace frequently used (-)-shikimic acid or (-)-quinic acid as the starting material. Ring-closing metathesis and diastereoselective Grignard reactions successfully served as the key steps. Absolute configurations of the key intermediates were confirmed by corresponding two-dimensional NMR studies.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000238665500037
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21077
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Cong X,Yao ZJ. Ring-closing metathesis-based synthesis of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxycyclohex-1-ene-carboxylic acid ethyl ester: A functionalized cycloalkene skeleton of GS4104[J]. J. Org. Chem.,2006,71(14):5365-5368.
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