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学科主题: 生命有机化学
题名: Bidirectional synthesis of the central amino acid of chloptosin
其他题名: Chloptosin主要核心氨基酸的双向合成
作者: Hong WX(洪文旭) ; Chen LJ(陈玲君) ; Zhong CL(仲春龙) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Org. Lett.
发表日期: 2006
卷: 8, 期:21, 页:4919-4922
收录类别: SCI
部门归属: 中科院上海有机所; 中国科技大学
英文摘要: An efficient total synthesis of (2S,2'S,3aR,3'aR,8aR,8a R)-6,6'-dichloro-3a,3'a-dihydroxy-1,1',2,2', 3,3a,3',3'a,8,8a,8',8'a-dodecahydro-5,5'-bipyrrol[2,3-b]indole-2,2'-dica rboxylic acid, the central amino acid component of chloptosin (1), is described. Starting from m-chloronitrobenzene, this C-2-symmetrical amino acid was synthesized by using a 14-step route, in which a Zinin benzidine rearrangement, intramolecular Heck reaction, and selenocyclization and oxidative deselenation served as key steps. The absolute stereochemistry of the target was confirmed by X-ray single-crystal studies on a key intermediate (17).
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000241030900063
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21075
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Hong WX,Chen LJ,Zhong CL,et al. Bidirectional synthesis of the central amino acid of chloptosin[J]. Org. Lett.,2006,8(21):4919-4922.
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