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学科主题: 生命有机化学
题名: Bromoetherification-based strategy towards the spirocyclic chromophore of chlorofusin
其他题名: Bromoetherification-based strategy towards the spirocyclic chromophore of chlorofusin
作者: Wei WG(魏万国) ; Qian WJ(钱文建) ; Zhang YX(张永霞) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Tetrahedron Lett.
发表日期: 2006
卷: 47, 期:25, 页:4171-4174
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: A short and direct route to the racemic model chromophore of the potent p53-MDM2 antagonist, chlorofusin, is presented. The spirocyclic chromophores were successfully constructed in high yields by an NBS-mediated intramolecular haloetherification. Ring expansion was observed in the subsequent reaction of the bromides with silver nitrate in refluxing acetone and water. Conversion of the bromides to the desired ketones was finally achieved by NMO oxidation. All four possible isomeric chromophores were finally synthesized and unambiguously characterized by X-ray crystallography studies. (c) 2006 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000238111400017
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21073
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wei WG,Qian WJ,Zhang YX,et al. Bromoetherification-based strategy towards the spirocyclic chromophore of chlorofusin[J]. Tetrahedron Lett.,2006,47(25):4171-4174.
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