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学科主题: 生命有机化学
题名: Synthesis of a tetra-deuterium-labeled derivative of potent and selective anticancer agent AA005
其他题名: Synthesis of a tetra-deuterium-labeled derivative of potent and selective anticancer agent AA005
作者: Liu HX(刘海侠) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Tetrahedron Lett.
发表日期: 2005
卷: 46, 期:20, 页:3525-3528
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: Annonaceous acetogenins are a series of potent naturally occurring anticancer agents, which act as inhibitors of complex I in mitochondria. AA005, a mimicry of acetogenins, has been found as active as those natural products and to present high selectivities between cancer and normal cells. In order to investigate the further cell-based mechanism induced by AA005, a d(4)-labeled derivative of AA005 (AA005-d(4)) was designed to detect the drug permeation ability into the membranes. In this letter, the synthesis is reported of this deuterium-labeled compound, wherein a ethylene-d(4) glycol unit is incorporated efficiently into the molecule skeleton by simple etherifications. © 2005 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000228872300020
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21063
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Liu HX,Yao ZJ. Synthesis of a tetra-deuterium-labeled derivative of potent and selective anticancer agent AA005[J]. Tetrahedron Lett.,2005,46(20):3525-3528.
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