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学科主题: 生命有机化学
题名: Stereoselective synthesis of new modified conformationally constrained L-tyrosine analogue with potential applications to SH2 domain ligands
其他题名: Stereoselective synthesis of new modified conformationally constrained L-tyrosine analogue with potential applications to SH2 domain ligands
作者: Liu F(刘发) ; Hu TS(胡泰山) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Tetrahedron
发表日期: 2005
卷: 61, 期:21, 页:4971-4981
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: This paper reports the stereoselective synthesis of a modified tricyclic tyrosine analogue 3, whose conformation is constrained by the covalent bonds and designed on the basis of X-ray and solution structures of SH2 domain and its natural peptide ligand. A Michael addition followed by an alkylation in high stereoselections, a Friedel-Crafts and a Mannich reaction-based cyclization served as the key steps in the synthesis. (c) 2005 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000229142800010
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21061
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Liu F,Hu TS,Yao ZJ. Stereoselective synthesis of new modified conformationally constrained L-tyrosine analogue with potential applications to SH2 domain ligands[J]. Tetrahedron,2005,61(21):4971-4981.
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