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学科主题: 生命有机化学
题名: Efficient synthesis of a new conformation-constrained L-Tyrosine analogue as potetial SH2 Domiain inhibitors scaffold
其他题名: 一种新的构象限制的L-酪氨酸类似物作为潜在的SH2功能域配体骨架的有效合成
作者: Cha HY(查慧艳) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: J. Org. Chem.
发表日期: 2003-01-01
卷: 68, 期:17, 页:6679-6684
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: the enantioselective synthesis of a new tricyclic tyrosine analogue is reported. This conformation contrained SH2 domain ligand scaffold 2 was designed on the basis of the natural ligand. Whose structure contains the elements of a tyrosine moiety having X1 and X2 angles constrained to values observed for a phosphotyrosyl (pTyr) residue bound to the p56kk SH2 domain. It represents a unique, highly constrained amino acid, which may be of value in signal transduction strudies. Three key steps, an asymmetric tandem Michael addition. An intramolecular Friedel-Crafts reaction, and an intramolecular mannich reaction, were successfully applied in the jpresented synthetic route.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/21039
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Cha HY,Yao ZJ. Efficient synthesis of a new conformation-constrained L-Tyrosine analogue as potetial SH2 Domiain inhibitors scaffold[J]. J. Org. Chem.,2003,68(17):6679-6684.
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