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学科主题: 天然产物有机化学
题名: Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b
其他题名: 大环内酯iriomoteolide-1b的对映选择性全合成
作者: Ye ZQ(叶正清) ; Gao TY(高婷轶) ; Zhao G(赵刚)
通讯作者: 赵刚
刊名: Tetrahedron
发表日期: 2011
卷: 67, 期:33, 页:5979-5989
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: An enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b has been achieved by a convergent protocol, which was featured by an enantioselective organocatalytic transfer hydrogenation of enal, a Julia-Kocienski olefination to establish the C15-C16 E-olefin moiety, a Kulinkovich reaction associated with cyclopropyl-allyl rearrangement to produce allyl stannane and ytterbium triflate and carboxylic acid promoted allylation between allyl stannane and aldehyde with tertiary alcohol at the alpha-position. The construction of macrolide 2 was realized by the successful implementation of RCM utilizing 5 mol % Grubbs's second generation catalyst at room temperature with E-isomer as a single product. (C) 2011 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000293606200017
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20817
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Ye ZQ,Gao TY,Zhao G. Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b[J]. Tetrahedron,2011,67(33):5979-5989.
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