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学科主题: 有机化学
题名: Highly Enantioselective Michael Addition of alpha-Substituted Cyano Ketones to beta,gamma-Unsaturated alpha-Keto Esters using Bifunctional Thiourea-Tertiary Amine Catalysts: An Easy Access to Chiral Dihydropyrans
其他题名: 硫脲催化剂催化氰基乙酮和不饱和酮酸酯对映选择性迈克尔加成
作者: Zhao SL(赵胜利) ; Zheng CW(郑昌武) ; Wang HF(王海峰) ; Zhao G(赵刚)
通讯作者: 赵刚
刊名: Adv. Synth. Catal.
发表日期: 2009
卷: 351, 期:17, 页:2811-2816
收录类别: SCI
部门归属: 上海有机所
英文摘要: An asymmetric Michael addition of alpha-substituted cyano ketones to beta,gamma-unsaturated alpha-keto esters to form chiral dihydropyrans catalyzed by a series of alpha-amino acid-derived thiourea-tertiary amines is presented. A novel tyrosine-derived thiourea catalyst was identified as the optimal catalyst providing the desired product in 91-95% yields and with 90-96% ee at a low catalyst loading of 2.0 mol%. The utility of the reaction was exemplified by facile conversion of the dihydropyran product into pharmaceutically useful dihydropyridine.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000272392000010
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20773
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Zhao SL,Zheng CW,Wang HF,et al. Highly Enantioselective Michael Addition of alpha-Substituted Cyano Ketones to beta,gamma-Unsaturated alpha-Keto Esters using Bifunctional Thiourea-Tertiary Amine Catalysts: An Easy Access to Chiral Dihydropyrans[J]. Adv. Synth. Catal.,2009,351(17):2811-2816.
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