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学科主题: 天然产物有机化学
题名: A Concise Synthesis of (-)-Indolizidines 209D and 209B
其他题名: 一种简洁合成(-)-Indolizidines 209D和209B
作者: Wu H(武豪) ; Yu ML(俞梦龙) ; Zhang YZ(张亚竹) ; Zhao G(赵刚)
通讯作者: 赵刚
刊名: Chin. J. Chem.
发表日期: 2009
卷: 27, 期:1, 页:183-188
收录类别: SCI
部门归属: 上海有机所
英文摘要: A general stereoselective synthetic route to 5-substituted and 5,8-disubstituted indolizidine alkaloids has been developed starting from commercially available L-proline. (-)-Indolizidines 209D and 209B were efficiently synthesized in 9.8% and 14.8% overall yields in seven and five-step reactions from readily available aldehyde 3 and ketone 10, respectively. The key steps of this synthesis involve a substrate-induced asymmetric addition of ethyl lithiopropiolate to aldehyde 3 or methyl ketone 10. and a two-step one-pot hydrogenation/cyclization sequence to construct the bicyclic skeleton.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000264039400031
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20767
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Wu H,Yu ML,Zhang YZ,et al. A Concise Synthesis of (-)-Indolizidines 209D and 209B[J]. Chin. J. Chem.,2009,27(1):183-188.
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