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学科主题: 天然产物有机化学
题名: Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine
其他题名: 高分子负载手性磺酰胺催化一锅法还原β-羰基腈:一种合成(R)-氟西汀和度洛西汀使用的方法
作者: Wang GY(王广印) ; Liu XS(刘新顺) ; Zhao G(赵刚)
通讯作者: 赵刚
刊名: Tetrahedron-Asymmetry
发表日期: 2005
卷: 16, 期:10, 页:1873-1879
收录类别: SCI
部门归属: 上海有机化学所现代有机化学研究室
英文摘要: Enantioselective reduction of beta-keto nitriles to optically active 1,3-amino alcohols has been carried out in one Step using an excess of borane-dimethyl sulfide complex as a reductant and a polymer-supported chiral sulfonamide as a catalyst with moderate to high enantioselectivity. The facile and enantioselective method to prepare optically active 1,3-amino alcohols to be converted into 3-aryloxy-3-arylpropyl imiiie-type antidepressant drugs (R)-fluoxetine, and (R)-duloxetine is also reported. (C) 2005 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000229529800019
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20685
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Wang GY,Liu XS,Zhao G. Polymer-supported chiral sulfonamide catalyzed one-pot reduction of beta-keto nitriles: a practical synthesis of (R)-fluoxetine and (R)-duloxetine[J]. Tetrahedron-Asymmetry,2005,16(10):1873-1879.
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