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学科主题: 天然产物有机化学
题名: 用高效液相色谱手性固定相法拆分芳香仲醇及芳香乙二醇类手性化合物
其他题名: Enantiomeric resolution of secondary aromatic alcohols and arylethanediols by HPLC on chiral stationary phase
作者: 夏立钧 ; 唐民华 ; 胡建兵 ; 丁左定 ; 金浩 ; 赵刚
通讯作者: 夏立钧
刊名: 有机化学
发表日期: 2002-01-01
卷: 22, 期:1, 页:60-63
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所分析化学实验室
摘要: 在Chiracel OD和 Chiralcel OJ 两支多糖类手性固定相上,以各种不同配比的正己烷—异丙醇为洗脱剂对38种带有不同取代基的芳香仲醇及芳香乙二醇类手性化合物的对映体进行拆分.考察了这些外消旋体在这两支手性柱上的色谱行为.结果表明,手性柱对这些化合物的拆分能力与化合物取代基的性质和位置有关,这些化合物与手性固定相之间的氢键作用和 π-π作用是影响手性拆分的重要原因.拆分方法已应用于潜手性酮不对称还原产物的光学纯度的鉴定,井取得了很好的效果.
英文摘要: Separation of racemic mixtures of thirty-eight secondary aromatic alcohols and arylethanediols with different sustituting group was achieved with HPLC by using Chiralcel OD and Chiralcel Oj as chiral stationary phase and hexane/2-propanol mixtures of different ratios as eluents. The chromatogrphic parameters of these racemates on OD and OJ columns were examined. The resulats showed enantiomeric resolution ability of the racemic mixtures on these columns was strongly dependent on the site and the property of substituents. The hydrogen bonding and π-π interactions between the chiral stationary phase and the polar group of secondary aromatic alcohols and arylethanediols may be responsibel for the chiral resolution. This method had been applied to determination of the optical purity of the asymmetric reduction products of prochiral ketones.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20653
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
夏立钧,唐民华,胡建兵,等. 用高效液相色谱手性固定相法拆分芳香仲醇及芳香乙二醇类手性化合物[J]. 有机化学,2002,22(1):60-63.
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