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学科主题: 金属有机化学 ; 氟化学
题名: Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids
其他题名: 钛参与下直接生成含不饱和双键的α-三氟甲基酸类化合物: Knoevenagel反应的新应用以及高效立体选择性合成α-三氟甲基丙烯酸类化合物新方法
作者: Liu YM(刘艳妹) ; Lai H(赖华) ; Rong B(容波) ; Zhou T(周铁) ; Hong J(洪家) ; Yuan C(袁超) ; Zhao SJ(赵淑静) ; Zhao XL(赵小龙) ; Jiang B(姜标) ; Fang Q(房强)
通讯作者: 房强
刊名: Adv. Synth. Catal.
发表日期: 2011-01-01
卷: 353, 期:17, 页:3161-3165
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 秦始皇兵马俑博物馆
英文摘要: An efficient strategy for a high-yielding and stereoselective synthesis of a-trifluoromethyl unsaturated carboxylic acids directly from the reactions of 3,3,3-trifluoropropanoic acid (CF(3)CH(2)COOH) with various aryl aldehydes in the presence of titanium tetrachloride (TiCl(4)) is reported here for the first time, which is a valuable expansion for the classical Knoevenagel reaction. Because these compounds may have potential applications in organic electronics and can be easily converted to the corresponding fluorinated alcohols and amino acids with excellent bioactivity, this route should be a good choice for the preparation of alpha-trifluoromethyl-containing derivatives.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000298171500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20289
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Liu YM,Lai H,Rong B,et al. Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids[J]. Adv. Synth. Catal.,2011,353(17):3161-3165.
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