中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 中科院天然产物有机化学重点实验室  > 期刊论文
学科主题: 氟化学
题名: The first highly enantioselective alkynylation of chloral: A practical and efficient pathway to chiral trichloromethyl propargyl alcohols
其他题名: 端炔烃对三氯乙醛的高对映选择性炔化方法:手性三氯甲基炔丙醇化合物的实用、有效制备方法
作者: Jiang B(姜标) ; Si YG(司玉贵)
通讯作者: 姜标
刊名: Adv. Synth. Catal.
发表日期: 2004-01-01
卷: 346, 期:6, 页:669-674
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所金属有机化学实验室
英文摘要: A new, inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N,N-dimethylamino-1-(4-nitrophenyl)-3-(tert-butyloxy)propan-1- ol, was developed for the asymmetric alkynylation of chloral in high yield with up to 98% ee. The resulting chiral adduct (S)-1-trichloromethyl-3-phenyl-2-propyn-1-ol was hydrogenated over 10% Pd/C to give the useful intermediate chiral trichloromethyl carbinol in quantitative yield, which was efficiently transformed into the pharmaceutically important building blocks 2-hydroxy-4-phenylbutanoate and homophenylalanine in high yield with excellent enantiomeric excess.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000222129300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20195
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2004146.pdf(111KB)----开放获取--View Download

Recommended Citation:
Jiang B,Si YG. The first highly enantioselective alkynylation of chloral: A practical and efficient pathway to chiral trichloromethyl propargyl alcohols[J]. Adv. Synth. Catal.,2004,346(6):669-674.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[姜标]'s Articles
[司玉贵]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[姜标]‘s Articles
[司玉贵]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2004146.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace