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学科主题: 天然产物有机化学
题名: Structure-based 3-D-QSAR analysis of marine indole alkaloids
其他题名: 海洋吲哚生物碱的3-DQSAR结构分析
作者: Jiang B(姜标) ; Xiong WN(熊文南) ; Yang CG(杨财广) ; Jiang HL(江华良) ; Chen F(陈峰) ; Chen KX(陈凯先)
通讯作者: 姜标
刊名: Bioorg. Med. Chem.
发表日期: 2002
卷: 10, 期:8, 页:2775-2778
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所金属有机化学开放实验室; 中国科学院上海药物所
英文摘要: A 3-D-QSAR study has been performed on these indole alkaloid derivatives to correlate their chemical structureswith their observed antitumor activity against IGROVI. Due to the absence of information on their active mechanism. Comparative molecular field analysis (CoMFAS) has been applied. A model able to well correlate the antitumor activity with the chemical structures of mono and bis(indole)alkaloids 1-18 has been developed which is potentially helpful in the design of novel and more potent antitumor agents.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000176294500036
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20143
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Jiang B,Xiong WN,Yang CG,et al. Structure-based 3-D-QSAR analysis of marine indole alkaloids[J]. Bioorg. Med. Chem.,2002,10(8):2775-2778.
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