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学科主题: 天然产物有机化学
题名: Synthesis of novel analogues of marine indole alkaloids: mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines as potential anticancer agents
其他题名: 新型海洋吲哚生物碱类似物的合成:作为抗肿瘤试剂的单吲哚-4-三氟甲基吡啶和双吲哚-4-三氟甲基吡啶
作者: Xiong WN(熊文南) ; Yang CG(杨财广) ; Jiang B(姜标)
通讯作者: 姜标
刊名: BIOORG. MED. CHEM.
发表日期: 2001
卷: 9, 期:7, 页:1773-1780
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所金属有机化学开放实验室
英文摘要: Mono(indoly)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylyridines were synthesized using Suzuki cross-coupling reaction between 2-chloro-4-trifluoromethylpyridine 9, 2,6-dichloro-4-trifluoromethylpyridine 6 or 2,6-dichloro-3-cyano-4-trifluromethylpyridine 23 and N-tosyl-3-indolyboronic acid 10. The were evaluated for cytotoxic activity against P388 and A-549 cellswith IC^50 values. 4-Trifluromethyl-2,6-bis[3'-(N-tosyl-6'methoxylindolyl)]pyridine 18 was identifed as the most potent in this series.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000169580500016
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20137
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Xiong WN,Yang CG,Jiang B. Synthesis of novel analogues of marine indole alkaloids: mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines as potential anticancer agents[J]. BIOORG. MED. CHEM.,2001,9(7):1773-1780.
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