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学科主题: 天然产物有机化学
题名: Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents
其他题名: 作为潜在的抗肿瘤试剂的新型吲哚嘧啶和吲哚哌嗪的合成以及毒性筛选
作者: Jiang B(姜标) ; Yang CG(杨财广) ; Xiong WN(熊文南) ; Wang J(王骏)
通讯作者: 姜标
刊名: BIOORG. MED. CHEM.
发表日期: 2001
卷: 9, 期:5, 页:1149-1154
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所金属有机化学开放实验室
英文摘要: Novel indolylpyrimidines and indolypyrazines have been synthesized as potential antitumor agents. They were screened in a panel of 60 human tumor cell lines in vitro Compounds 7,9,10,15,21 exhibited effciently cytotoxic activities with GI^50 vlues in the low micromolar range against a variety of human cancer cell lines. 2,4-Bis (3'-indolyl)pyrimidine 8 displayed selective cytotoxic activity against IGROV1 tumor cell line with the GI^50 value below 0.01μM.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000169010100009
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20123
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Jiang B,Yang CG,Xiong WN,et al. Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents[J]. BIOORG. MED. CHEM.,2001,9(5):1149-1154.
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