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学科主题: 天然产物有机化学
题名: Syntheses and cytotoxicity evaluation of bis(indoly)thiazole, bis(indolyl)pyrazinone and bis(indolyl)pyrazine: Analogues of cytotoxic marine bis(indole)alkaloid
其他题名: 双吲哚噻唑、双吲哚吡嗪酮及双吲哚吡嗪的合成及毒理估测: 胞毒海洋双吲哚生物碱类似物
作者: Jiang B(姜标) ; Gu XH(谷晓辉)
通讯作者: 姜标
刊名: BIOORG. MED. CHEM.
发表日期: 2000-01-01
卷: 8, 页:363-371
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所现代有机化学实验室
英文摘要: 2,4-Bis(3'-indolyl)thiazoles, 3,5-bis(3'-indolyl)-2(lThpyrazinone and 3,6-bis(3'-indolyl)pyrazine were synthesized and evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. These compounds demonstrated significant inhibitory effects in the growth of a range of cancer cell lines. 2,4-Bis(3'-indolyl)thiazole displayed selective cytoxictity against certain leukemia cell lines with CI^50 values in the low micromolar range while the substituted derivatives shbwed a broad spectrum of cytotoxic activity. 3,5-Bis(3'-indolyl)-2(1H)pyrazinone and 3,6-bis[3'-(N-methyl-indolyl)Jpyrazine possessed strong inhibitory activity against a wide range of human tumor cell lines. The mechanism of action remained unknown. The tesults suggested that 2,4-bis(3'-indolyl)thiazoles, 3,5-bis(3'-indolyl)-2(1H)pyrazinone and 3,6-bis(3'-(N-methyl-indolyl)] pyra-tine offer potential as lead compounds for the discovery of anticancer agents.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20105
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Jiang B,Gu XH. Syntheses and cytotoxicity evaluation of bis(indoly)thiazole, bis(indolyl)pyrazinone and bis(indolyl)pyrazine: Analogues of cytotoxic marine bis(indole)alkaloid[J]. BIOORG. MED. CHEM.,2000,8:363-371.
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