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学科主题: 分析化学
题名: Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report
其他题名: Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report
作者: WANG J ; ZHOU Y ; XU M ; RANG R ; Guo YL(郭寅龙) ; Zhu TY(朱同玉)
通讯作者: 朱同玉
刊名: Transplant. Proc.
发表日期: 2011
卷: 43, 期:10, 页:3738-3742
收录类别: SCI
部门归属: 复旦大学中山医院; 中科院上海有机化学研究所
英文摘要: Acute tubular injury (AT!) is very common in biopsy specimens from renal allografts that suffer from delayed graft function (DGF) or dysfunction. Currently there are few reports on investigating small molecule metabolites in urine samples from transplant recipients as a noninvasive method to predict the ATI of renal allografts instead of an allograft biopsy. In our study matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS) was used to analyze small molecule metabolites in urine samples from renal transplant recipients with biopsy-proven slight ATI or moderate ATI or acute tubular necrosis (ATN). To evaluate the ATI-specific value of those small molecules, we applied the Principal Component Analysis (PCA) program. Mass spectra data were imported into the PCA, where loading graphs were constructed to express the constituents of the urine samples. Slight AT!, moderate ATI, or ATN of renal allografts were separated obviously in the loading graph. The position of urine samples in the graph may reflect the tubular injury status of allografts. A farther apart point from the original site may mean the allograft suffered from more severe AT! (even ATN), and vice versa. Detection of small molecule metabolites in urine samples of recipients through MALDI-FTMS may offer a promising noninvasive, high throughput, rapid tool to predict ATI/ATN of renal allografts.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000298620200031
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20062
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
WANG J,ZHOU Y,XU M,et al. Urinary Metabolomics in Monitoring Acute Tubular Injury of Renal Allografts: A Preliminary Report[J]. Transplant. Proc.,2011,43(10):3738-3742.
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