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学科主题: 分析化学
题名: Analysis of low molecular weight compounds by MALDI-FTICR-MS AND LIFE SCIENCES
其他题名: 激光解吸离子化傅立叶质谱法研究小分子化合物
作者: Wang HY(王昊阳) ; Xu C(许楚) ; Zhao ZX(赵志雄) ; He XS(贺小双) ; Guo YL(郭寅龙)
通讯作者: 王昊阳 ; 郭寅龙
刊名: J. Chromatogr. B
发表日期: 2011-01-01
卷: 879, 期:17-18, 页:1166-1179
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: This review focuses on recent applications of matrix-assisted laser desorption ionization-Fourier-transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS) in qualitative and quantitative analysis of low molecular weight compounds. The scope of the work includes amino acids, small peptides, mono and oligosaccharides, lipids, metabolic compounds, small molecule phytochemicals from medicinal herbs and even the volatile organic compounds from tobacco. We discuss both direct analysis and analysis following derivatization. In addition we review sample preparation strategies to reduce interferences in the low m/z range and to improve sensitivities by derivatization with charge tags. We also present coupling of head space techniques with MALDI-FTICR-MS. Furthermore, omics analyses based on MALDI-FTICR-MS were also discussed, including proteomics, metabolomics and lipidomics, as well as the relative MS imaging for bio-active low molecular weight compounds. Finally, we discussed the investigations on dissociation/rearrangement processes of low molecular weight compounds by MALDI-FTICR-MS. (C) 2011 Elsevier B.V. All rights reserved.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/20038
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Wang HY,Xu C,Zhao ZX,et al. Analysis of low molecular weight compounds by MALDI-FTICR-MS AND LIFE SCIENCES[J]. J. Chromatogr. B,2011,879(17-18):1166-1179.
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