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学科主题: 分析化学
题名: Identification of two herbal compounds with potential cholesterol-lowering activity
其他题名: 两种具有潜在降胆固醇活性的中药化合物的鉴定研究
作者: Zhang YL(张宜林) ; Zhang HQ(张海青) ; Hua SN(华时能) ; Ma LH(马梁辉) ; Chen C(陈聪) ; Liu XY(刘晓玉) ; Jiang LQ(蒋利群) ; Yang HM(杨焕明) ; Zhang PC(张培成) ; Yu DQ(于德全) ; Guo YL(郭寅龙) ; Tan XH(谭学海) ; Liu JF(刘建峰)
通讯作者: 谭学海 ; 刘建峰
刊名: Biochem. Pharmacol.
发表日期: 2007-01-01
卷: 74, 期:6, 页:940-947
收录类别: SCI
部门归属: 北京基因研究所; 上海HD生物科技公司; 华中理工大学; 北京大学医学院; 上海有机所上海质谱中心
英文摘要: Low-density lipoprotein receptor (LDLR) plays a pivotal role in the control of plasma LDL-cholesterol level. This occurs predominantly at the transcriptional level through two gene regulation elements, named SRE: sterol- responsive element and SIRE: sterol-independent responsive element. We have developed a high-throughput screening using LDLR promoter activation -based assay to search for cholesterol-lowering compounds from a Chinese herb-based natural compound library. With this approach, we identified two compounds, named Daphnetoxin and Gniditrin, from Chinese herb Daphne giraldii Nitsche, which could activate LDLR promoter. Characterization of these compounds showed that they increased the level of LDLR mRNA and consequently up-regulate LDLR expression. The structures of these compounds are different from well-known LDLR promoter activating compounds such as GW707. The results suggested that these herbal compounds could represent good candidates for development of new classes of cholesterol-lowering drugs. (C) 2007 Elsevier Inc. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000249323800015
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19952
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Zhang YL,Zhang HQ,Hua SN,et al. Identification of two herbal compounds with potential cholesterol-lowering activity[J]. Biochem. Pharmacol.,2007,74(6):940-947.
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