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Identification of two herbal compounds with potential cholesterol-lowering activity
Alternative Title两种具有潜在降胆固醇活性的中药化合物的鉴定研究
Zhang YL(张宜林); Zhang HQ(张海青); Hua SN(华时能); Ma LH(马梁辉); Chen C(陈聪); Liu XY(刘晓玉); Jiang LQ(蒋利群); Yang HM(杨焕明); Zhang PC(张培成); Yu DQ(于德全); Guo YL(郭寅龙); Tan XH(谭学海); Liu JF(刘建峰)
Source PublicationBiochem. Pharmacol.
AbstractLow-density lipoprotein receptor (LDLR) plays a pivotal role in the control of plasma LDL-cholesterol level. This occurs predominantly at the transcriptional level through two gene regulation elements, named SRE: sterol- responsive element and SIRE: sterol-independent responsive element. We have developed a high-throughput screening using LDLR promoter activation -based assay to search for cholesterol-lowering compounds from a Chinese herb-based natural compound library. With this approach, we identified two compounds, named Daphnetoxin and Gniditrin, from Chinese herb Daphne giraldii Nitsche, which could activate LDLR promoter. Characterization of these compounds showed that they increased the level of LDLR mRNA and consequently up-regulate LDLR expression. The structures of these compounds are different from well-known LDLR promoter activating compounds such as GW707. The results suggested that these herbal compounds could represent good candidates for development of new classes of cholesterol-lowering drugs. (C) 2007 Elsevier Inc. All rights reserved.
Subject Area分析化学
Department北京基因研究所; 上海HD生物科技公司; 华中理工大学; 北京大学医学院; 上海有机所上海质谱中心
Indexed BySCI
WOS IDWOS:000249323800015
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorTan XH(谭学海); Liu JF(刘建峰)
Recommended Citation
GB/T 7714
Zhang YL,Zhang HQ,Hua SN,et al. Identification of two herbal compounds with potential cholesterol-lowering activity[J]. Biochem. Pharmacol.,2007,74(6):940-947.
APA 张宜林.,张海青.,华时能.,马梁辉.,陈聪.,...&刘建峰.(2007).Identification of two herbal compounds with potential cholesterol-lowering activity.Biochem. Pharmacol.,74(6),940-947.
MLA 张宜林,et al."Identification of two herbal compounds with potential cholesterol-lowering activity".Biochem. Pharmacol. 74.6(2007):940-947.
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