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学科主题: 分析化学
题名: Oxidized carbon nanotubes as matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of biomolecules
其他题名: 氧化碳纳米管作为基质用于生物分子的MALDI-TOF MS分析
作者: Ren SF(任士芳) ; Guo YL(郭寅龙)
通讯作者: 郭寅龙
刊名: Rapid Commun. Mass Spectrom.
发表日期: 2005
卷: 19, 期:2, 页:255-260
收录类别: SCI
部门归属: 上海有机化学研究所
英文摘要: Oxidized carbon nanotubes (CNTs), which can form a stable homogeneous suspension in water close to a solution phase, were synthesized and used for matrix-assisted desorption/ionization mass spectrometric (MALDI-MS) analysis of biomolecules. Infrared (IR) spectra, transmission electron microscopy (TEM) and particle size analysis were used for the characterization of the oxidized CNTs. The results indicate that the physical structure of the CNTs was not damaged, but carboxylate groups were introduced onto the surface of the CNTs. In addition, impurities including amorphous carbon, which is one of the main reasons for ion source contamination, were destroyed by the oxidization. The carboxyl groups on the oxidized surface of the CNTs can not only provide an additional proton source, but can also increase the surface polarity and solubility of the CNTs, making it easier to manipulate which is important for MALDI analysis of some biomolecules, especially larger peptides and proteins. The oxidized CNTs were successfully applied to the analysis of neutral oligosaccharides, peptides, and insulin, and thus promise to be an efficient matrix for MALDI-MS analysis of biomolecules. Copyright (C) 2004 John Wiley Sons, Ltd.
语种: 英语
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WOS记录号: WOS:000226603700025
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19908
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Ren SF,Guo YL. Oxidized carbon nanotubes as matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of biomolecules[J]. Rapid Commun. Mass Spectrom.,2005,19(2):255-260.
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