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学科主题: 分析化学
题名: 红霉素类抗生素电喷雾/飞行时间质谱源内CID研究
其他题名: The in source CID study of erythromycin analogue artibiotic in electrospray ionization/time of flight mass spectrometry
作者: 胡守刚 ; 郭寅龙 ; 吕龙
刊名: 质谱学报
发表日期: 2001-01-01
卷: 22, 期:2, 页:10-16
部门归属: 中国科学院上海有机化学研究所分析化学实验室
英文摘要: In-source CID of electrospray ionization (ESI)/time-of-flight mass spectrometry(TOF-MS) was applied to five erythromycin analogue antibiotics. Using polyethylene glycol(PEG) and the protonated molecular ion (MH+) as internal reference compounds, the accurate mass of the fragment ions were determined, The fragment ions were elucidated, and their framentation patterns were discussed. Erythomycin analogue antibiotics containing structure segments, Desosamine or Cladinose, have more powerful ability to form adduct ions with H+ in acid condition. Desosamine can easily form positive ions. The effects of Nozzle potenitial and solvents on erythromycin analogue antibiotics of in-soure CID og electrospray ionizaion (ESI) were studied. In company with Nozzle potential rising, the relative abundance of the fragment ions to the protonated molecular ion (MH+) first increases, but after Nozle potential reaches to certain value, it begins to decrease. The higher nozzle potential becomes, the more easily the protonated molecular ion (MH+)methylateswith CH^3OH in solvents to form (MH~+ +CH^3OH-H^2O) And increasing nozle potential can make the relative abundance of Mna+、MK~+ rise. Suitable nozle potential and acid condition were recommended.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/19792
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
胡守刚,郭寅龙,吕龙. 红霉素类抗生素电喷雾/飞行时间质谱源内CID研究[J]. 质谱学报,2001,22(2):10-16.
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